Nail Polish Science,
Brand Strategy & 2026 Trends

"HEMA was present in nearly 60% of 394 cosmetic nail products surveyed. Mandatory warnings on packages of HEMA-containing products were absent in 35% ('For professional use only') and 55% ('Can cause an allergic reaction')."

A 2023 analysis of labels of 394 nail cosmetics from the Netherlands, Poland, China, and USA identified 18 acrylates and 29 methacrylates — HEMA was the most identified component, present in 229 products. The review also documents the historical progression of toxic ingredient restriction from formaldehyde to toluene sulfonamide to (meth)acrylates.

Comprehensive two-part clinical review covering HEMA allergy epidemiology, sensitization cross-reactivity, skin reactions, and practical guidance for dermatologists and cosmetic formulators. Part 2 specifically documents HEMA's presence in commercial nail cosmetic products and provides patch test protocols for clinical identification.

An audit of 13 UK and Irish dermatology units tested 4,931 patients for (meth)acrylate allergy. Results: 1.5% tested positive to HEMA — the most common (meth)acrylate to cause allergic sensitization. 2.4% tested positive to at least one acrylate type. The BAD issued a formal 2018 warning that (meth)acrylate chemicals in gel nails are causing a "contact allergy epidemic." This data directly informs LuxeFormula Labs' HEMA-free gel polish formulation program.